Beilstein J. Org. Chem.2020,16, 638–644, doi:10.3762/bjoc.16.60
; difluoromethyl compounds; fluorinateddiazoreagents; strong Brønsted acids; Introduction
Chiral aziridines are prevalently found in natural products and artificially made bioactive molecules, thus receiving significant attention in the past decades [1][2][3][4][5][6]. Among them, the introduction of fluorine
dichloromethane/petroleum ether) to give CF2-substituted aziridine 4. The enantiomeric excess was determined by chiral HPLC analysis. See Supporting Information File 1 for the dissolution–filtration procedure for each compound.
Preparation of chiral aziridines from fluorinateddiazoreagents.
Substrate scope of
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Graphical Abstract
Scheme 1:
Preparation of chiral aziridines from fluorinated diazo reagents.